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LECs III are characterized by the expression of microfibril associated protein 4 (MFAP4) and LYVE1

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The primary contributors to ROS production reside in the mitochondria, which supply over 90% of cellular ROS ( 2 - ) is generated through reactions catalyzed by complex I, II and III ( 2 O 2 ), which can freely diffuse into the cytosol ( Another important source of ROS in T cells is the family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, including NOX2 and DUOX2

Using liver-specific leukemia inhibitory factor receptor (LIFR) knockout mice, the authors demonstrated that hepatocyte LIFR promotes the secretion of CXCL1 and cholesterol in a STAT3-dependent manner, recruiting and activating neutrophils