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In our studys limitations, we acknowledge the relatively modest sample sizes for African, East Asian, Admixed American/Latino, and Middle Eastern populations, which may hinder the robustness of our GWAS findings in diverse ancestries

Ethics declarations Conflict of interest The authors declare that they have no competing interests to disclose

More recently, deletion of the DUB POH1 in macrophages was shown to increase IL-1 activation following treatment with NLRP3 stimuli 49

Cell Mol Neurobiol 38(8):15051516 McCord JM (2000) The evolution of free radicals and oxidative stress

FIGURE 3 FIGURE 4 3.3 Oxidative stress and inflammation in rat prostate tissue To verify whether the histological alterations observed were associated with oxidative stress and inflammatory processes, the immunoreactivity and distribution of key proteins involved in these pathways, specifically PECAM-1, NRF2, and HO-1, were evaluated