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TAMs, through their remarkable metabolic plasticity, modulate iron flux, redox balance, polyunsaturated fatty-acid (PUFA) availability, and glutathione-dependent antioxidant pathways, each of which directly influences ferroptotic vulnerability in neighboring tumor cells

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The reactivity of Cys with oxidants is known to be pH and environment sensitive, with this arising partly from the increased reactivity of the thiolate (RS ) over the neutral form 33 , but also from electronic and structural factors [cf

Statistical analyses Statistical analyses were conducted using SPSS Statistics software (v.28.0

(Marks, Cook et al