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However, an abundance of IL-10 also inhibits the function and proliferation of immune cells (e.g., Th1, NK cells, and CD8 T cells), which delays the clearance of viruses 99

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65% of iCCAs) are enriched in immunosuppressive M2-like macrophages and hyperactivated CD4 + regulatory T cells that induce a suppressive local immune milieu 119 , which is associated with FGFR2 fusions, mutations in IDH1/2 and BAP1 and co-occurrence of KRAS / TP53 mutations