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It has been proposed that ATXN3 contributes to facilitate the proteasomal degradation of ubiquitylated proteins by editing polyubiquitin chains of a subset of substrates prior to digestion [69] and to protect others from degradation [70,71,72]

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Against a backdrop of extensive COVID-19 vaccinations (70-80% coverage for most populations in developed countries), the coronavirus infection appears temporally proximal to the serious AE, making it the default suspect

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