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The rational design of amino acid sequences for stapled peptides emerges as a paramount approach when scientists aim to acquire stapled peptides with enhanced binding affinity, stability, and specificity towards target receptors beyond the natural ligands, or when the target receptor has undergone mutations that preclude the derivation of valuable design cues from natural ligands

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High molecular weight cross-linked products like Synvisc-One offer longer-lasting relief with single-injection convenience, while intermediate molecular weight non-cross-linked products like Euflexxa more closely mimic natural synovial fluid

PGC-1 mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

The chemical state and configuration of Cu were investigated by X-ray absorption spectroscopy from Shanghai Synchrotron Radiation Facility (SSRF), BL14W beamline