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Therefore, in PD Nrf2 activation and BBB preservation may cooperate to fight oxidative and inflammatory stressors [55]

For example, in TLR7 agonist-induced lupus mouse model, delayed treatment with 6-gingerol from week 4 and for 2 weeks greatly reduced plasma NET levels, autoantibody formation (e.g., anti-dsDNA and anti-2GPI antibodies), and thrombosis but not total leukocytes or spleen size (162)

Quest-ce que le collagne

doi: 10.3389/fmicb.2015.00742

[99] However, this concept was conclusively disproved when it was demonstrated that mice, which were genetically altered to accumulate mtDNA mutations at an accelerated rate to age prematurely, but their tissues do not produce more ROS as predicted by the 'Vicious Cycle' hypothesis