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Exogenous pyruvate can thus at least partially bypass the GOT1/2 defect and restore proliferation both in vitro and in vivo

Optional research biomarkers: senescence markers (p16^INK4a, SA--gal), SASP cytokine profile (IL-6, IL-1, MMPs) if lab resources permit

To determine molecular drivers of cancer, genetic screens have aided in elucidating genes regulating various processes such as cancer initiation, proliferation, and metastasis

DNA primase is crucial for initiating DNA replication and synthesizing Okazaki fragments during the synthesis of lagging strand (Shiratori et al., 1995

Other Articles Reynolds A, Ravandi-Kashani F, Medeiros L, Kornblau SM , Jabbour EJ, Jain N, Short NJ, Hu S, Wei Q, Loghavi S, Ok CY, Toruner G, Ling J, Liang S, Verma T, Zou YS, Wang SA Comprehensive Cytogenomic Profiling of T-Lymphoblastic Leukemia by Optical Genome Mapping and Next Generation Sequencing