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In populations who cannot exercise due to frailty, physical disability, or cardiovascular limitations, MOTS-c represents one of the most compelling candidates in the emerging class of pharmacological exercise mimetics

This can contaminate blood samples and lead to inaccurate readings

In response to OS, different metabolites oxidize highly reactive cysteine residues in KEAP1, inducing a conformational change in the KEAP1-NEDD8-CUL3-RBX1-E3 ubiquitin ligase complex, with an improper orientation of Lys residues on NRF2 [122, 158]

Regular screening is important for at-risk individuals

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