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John's wort: an update

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These findings suggest that Artesunate has an inhibitory effect on NSCLC (Zhang et al., 2008)

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The mechanism of action involves binding to GHS-R1a receptors located on the pituitary gland

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Discussion Collectively, these results suggested that ACTL6A, which contains a hydrophobic region, cooperates with NRF2 to regulate GCLC expression at the transcriptional level and then promotes GSH synthesis and inhibits the ferroptosis of GC cells

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However, considering that the human bodys endogenous antioxidant system is not sufficient, the human body can hardly produce nonenzymatic antioxidants, so it depends on exogenous nonenzymatic antioxidants, such as mineral elements, nutritional antioxidants, phytochemicals, cytoprotectants and synthetic compounds (Table 1) [34, 36]

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