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Critically, acute AMPK activation during ATP depletion exacerbates glycolytic overdrive and FAO, while chronic mTORC1 signaling in surviving neurons drives maladaptive lipid synthesis that fuels ferroptosis [111]

PI3K also promotes the combination of the ribosome and mTORC2, and the ribosome is necessary for inducing mTORC2 kinase activity [34]

J Clin Invest 34:622628 McKhann GM, Tower DB (1961) Ammonia toxicity and cerebral oxidative metabolism

In the lungs, the reverse reaction occurs, allowing CO to be exhaled and oxygen to bind hemoglobin for delivery to tissues (60)

N Engl J Med 369(21):20212030 MacAskill AF, Kittler JT (2010) Control of mitochondrial transport and localization in neurons