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The newly completed programs target major global pharmaceutical markets, including: Erectile dysfunction (estimated global market ~US$5 billion annually) Premature ejaculation (estimated global market ~US$3 billion) Anticoagulant therapies, including apixaban, one of the worlds leading cardiovascular medicines with global sales exceeding US$19 billion Key developments include: Rapid-delivery oral spray formulations for erectile dysfunction and premature ejaculation A novel dual-active spray combining treatments for two commonly co-occurring conditions Reformulation work on apixaban designed to improve solubility and enable alternative dosage formats These programs significantly expand EVEs reformulation pipeline and align with the Companys strategy of targeting established pharmaceutical compounds approaching patent expiry, where improved delivery formats can create new intellectual property and commercial opportunities

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Mahamud O, So J, Chua MLK, Bristow RG