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Physicians should also exercise caution when prescribing to patients with proliferative retinopathy or severe, uncontrolled diabetes, as GH can transiently affect insulin sensitivity

In a related study, mice that were fed a high fat diet had crown-like signs of macrophage infiltrations, while mice that were given a high fat diet and injected with SOD3 had minimal signs of infiltrate (Cui et al., 2014)