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We noted that the p K a of Cys1 in rChTg is 8.1 while both Cys50 and Cys45 show a lower p K a of 7.6 and 7.9, but they are almost unreactive toward GSSG

For detailed compound profiles including full chemical data, regulatory history, and extended study summaries, see the individual library entries: For structural context on the parent splice variant, see the MGF compound profile

Manufacturer: Elabscience Ascorbate Peroxidase (APX) can catalyze the reaction between ascorbic acid (ASA) and hydrogen peroxide (H2O2), and ASA can be oxidized to monodehydroascorbic acid (MDASA)

Instead, accumulating evidence indicates that Class IIa HDACs function primarily as transcriptional co-repressors by acting as scaffolding proteins [33, 38]

*Correspondence: Sheela Ramanathan, [email protected] These authors share first authorship These authors share senior authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers