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The paper reports the absence of the positive effect under twice-daily dosing rather than a measured decrement, and no head-to-head statistical comparison of the two schedules is given but even read at its most conservative, that is not how a dose-dependent hypnotic behaves

Rylski, B., Schilling, O

A.OrtenbladN.ZinnerC.Morales-AlamoD.WillisS

[DOI] [PMC free article] [PubMed] [Google Scholar] 146.Lanthier N, Rodriguez J, Nachit M, Hiel S, Trefois P, Neyrinck AM, Cani PD, Bindels LB, Thissen JP, Delzenne NM

Patients were assigned to either subcutaneous (250 mcg daily) or sublingual (1000 mcg daily) based on preference