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Under oxidative stress, NRF2 was released from KEAP1, translocated into and accumulated in the nucleus to induce expression of its target genes, and increased the expression of antioxidant enzymes like SODs and HOs families 60

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The principal cytochrome P450 isoenzyme involved appears to be CYP2E1, with CYP1A2 and CYP3A4 as additional pathways