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Female C3H/HeNCrNarl mice were used at 68 weeks of age (National Laboratory Animal Center, Taiwan)

MTHFR mutations are common

Alkaloids are synthesized primarily from amino acids and are present in the seeds, roots, stems, and leaves of certain higher plants, such as those in the Solanaceae, Ranunculaceae, Gentianaceae, Asparagaceae, Amaryllidaceae, and Papaveraceae families (168, 169)

2c), further supporting our conclusion that these animals accumulate excessive thiol antioxidants

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