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doi: 10.3389/fimmu.2022.918160 Received 12 April 2022 Accepted 15 June 2022 Published 07 July 2022 Volume 13 - 2022 Edited by Xi Tao, China Pharmaceutical University, China Reviewed by Bhrugu J

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73 HIF-1 promotes IL-1 production and drives inflammation by shifting activated macrophage metabolism from oxidative phosphorylation to glycolysis, with the resulting lactate serving as a key mediator of macrophage phenotype through epigenetic and chromatin-mediated gene regulation