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This occurs because high intensity stimulation generates a larger pool of active and dephosphorylated PKC, thus providing enough time for degradation pathways to interact with PKC and target it for down-regulation (Figure 6D: No HSP-60 overexpression case)

By integrating metabolomic profiling with advanced multivariable and network analyses, this study provides evidence that selected EDC are associated with metabolic alterations relevant to FHT, and highlight broader implications for comparative and environmental health, as indoor cats are widely recognized as important sentinels for human exposure

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