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ROS-dependent generation of lipid peroxidation products results in an increase in the level of small-molecule, unsaturated, reactive aldehydes (e.g., 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA)) and cyclization products, including iso- and neuroprostanes 9 , while the enzymatic hydrolysis of phospholipids promotes the increase in the level of endocannabinoids (with the participation of phospholipases and diacylglycerol (DAGL)) and free polyunsaturated fatty acids (PUFAs) (with the involvement of phospholipases A (PLAs))

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This leads to an increase in oxidative stress that produces more severe hangover symptoms

J., Rajan, A., Suriano, F

doi: 10.1007/s12035-011-8181-5