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BPS Publications bpspubs.onlinelibrary.wiley.com To view or add a comment, sign in Methylene Blue in Clinical Practice: From FDA-Approved Methemoglobinemia Reversal to Off-Label Applications, Serotonergic Risks, and Safety --- -- -- Dr Indunil Karunarathna Uva Clinical Research Lab 2026 Uva Clinical Anaesthesia and Intensive Care ISSN 2827-7198, 2026 Methylene blue (methylthioninium chloride) DOI:10.5281/zenodo.20674932 is a century-old synthetic thiazine dye with a distinctive pharmacodynamic profile that encompasses redox cycling, alternative electron transport, and enzymatic inhibition

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For example, pH-sensitive nanocarriers utilise the acidic conditions of the tumour microenvironment to trigger charge switching, enzyme-responsive systems to activate in the presence of tumour-associated enzymes, and redox-sensitive carriers to release drugs in response to elevated intracellular glutathione levels

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