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They should also be instructed about signs and symptoms that warrant dose adjustment or medical evaluation, including severe gastrointestinal side effects or other unusual symptoms that may indicate adverse reactions, as determined relevant by the prescribing clinician

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In CKD, this balance can be disrupted, leaving people with low calcium levels and an increased risk of osteoporosis or fractures

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This study was funded by the National Key R&D Program of China (2018YFA0801000) to X.F.D., and STI2030-Major Projects (2021ZD0204500 and 2021ZD0204502) to J.L.D