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Bibliometric analysis confirms intense research focus on microbiota-CKD interactions, particularly regarding disease mechanisms, probiotic therapies, and microbial metabolites ( Lactobacillus johnsonii , correlate strongly with CKD progression and uremic toxin accumulation

The potential for AIEC to modulate this hypoxic microenvironment is supported by their ability to induce NF-B (49), which increases transcription of HIF-1 mRNA (33, 42) and induction of HIF-dependent pathways in epithelial cells by AIEC LF82 (54)

Astragalus polysaccharide (APS), a biological macromolecule, is extracted from astragalus and has been reported to exhibit complex biological activities involved in intestinal barrier integrity maintenance, intestinal microbiota regulation, short-chain fatty acids (SCFAs) production, and immune response regulation, which are critical for intestine health

After the three blocks, 60 patients received an allogeneic HSCT, and 22 patients continued with a chemotherapy-only approach, which included three additional high-dose blocks