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Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig

Also, rapid bed-side stool antigen tests for H.pylori detection are now available for commercial use [16]

Nutlin-3, an inhibitor of murine double minute 2 (MDM2), enhances p53 stability and preserves intracellular GSH levels via a p53-dependent mechanism, allowing cell survival under cystine-deprived conditions (98)

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L-asparaginases also exhibit glutaminase activity required for durable therapeutic effects against acute lymphoblastic leukemia (243)