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Accumulation of the toxic metabolite can then exert untoward effects on key cellular structures and functions (Figure 1)

IV delivery maximizes effectiveness : Intravenous administration achieves 100% bioavailability compared to oral supplements' 2-10% absorption rate for both compounds

By not interacting with unrelated biological pathways, the peptide minimizes the risk of these broader complications

While the haem biosynthesis and degradation pathway has already been demonstrated to be synthetic lethal in FH-deficient cells, the role of GSH metabolism in FH-deficient cells has not been investigated before and required further investigation