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The core discrepancies may stem from two factors, first, distinct genetic backgrounds of mouse strains, with inherent differences in gut microbiota responses to disease between arthritis-susceptible and conventional models, and second, undefined Clostridium strains, which fail to rule out the possibility of pathogenic subtypes

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Positively charged and metal-doped CQDs show heightened oxidative and inflammatory responses, while negatively charged or hydrophilic CQDs remain generally safe