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Elevated GH secretion drives downstream IGF-1 production, mediated primarily through hepatic GH receptor signalling, and the GH/IGF-1 axis effects of ipamorelin including anabolic signalling in skeletal muscle, lipolytic activity in adipose tissue, and effects on bone metabolism have been studied in multiple preclinical models

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doi: 10.1056/NEJM198908313210906 [DOI] [PubMed] [Google Scholar] [52].Oschmann P, Dorndorf W, Hornig C, et al

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