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Desipramine activates MAPK signaling via ERK1/2 , JNK , and p38 , represses NF-B and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase

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Supporting evidence from studies on pomegranate peel has demonstrated that elevated phenolic content enhances free radical scavenging efficacy and reduces oxidative stress [65]