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Additionally, loss of the E3 ubiquitin ligase ( VHL ) that tags HIFs for degradation is linked to platinum resistance in renal cancer (Supplementary Table S1)

They do not allow conclusions about efficacy in humans

Typically, increased NADPH, which reduces glutathione, is able to compensate for elevated levels of oxidative stress caused by such triggers

Plant Physiol Biochem 166:448458 Huang S, Van Aken O, Schwarzlnder M, Belt K, Millar AH (2016) The roles of mitochondrial reactive oxygen species in cellular signaling and stress response in plants