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The explosive release of DAMPs in the early stage provides the necessary starting signal for activating antitumor immunity, while the depletion of DAMPs in the late stage leads to a decline in immunogenicity

The timeline difference is part of what informs which treatment to lead with for a given patient

doi: 10.1210/er.2002-0012 122 EnguixNPardoRGonzalezALopezVMSimRKralliAet al

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capsulatum , IFN enhances the expression of MHCI, promoting antigen presentation, phagocytosis, and macrophage responses (215218)