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At its most serious, it can cause life-threatening anaphylaxis (per DermNetNZ)

PMid:12743340 PMCid:PMC1742688 Butler CC, Vidal-Alaball J, Cannings-John R, et al

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[1] [8] As a dual agonist, tirzepatide activates both GIP and GLP-1 receptors, which are incretin hormones that play crucial roles in glucose homeostasis and metabolic regulation