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Bae et al., 2 O 2 leads to the oxidative stress-induced aggregation of -syn by crosslinking -syn tyrosine residues through dityrosine bonding (Hashimoto et al., 1999

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O 2 is the conjugate base of a weak acid HOO (de Grey 2002) Since superoxide does not react with DNA directly, in the context of DNA damage is of important dismutation reaction of superoxide radical Although the concentration of hydroperoxyl radical (HOO ) is low, this reaction is significantly faster than the uncatalyzed reaction involving two molecules of superoxide radical The superoxide anion radicals can be formed in biological systems as a consequence of thiol-mediated repair of radicals (R ) by thiols (RSH), resulting in the formation of thiyl radicals (RS ) (Valko et al

PMID: 23099431 Ghrelin signaling in VTA mediates reward-based feeding

J Alzheimers Dis 57:11051121