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7 Data represent mean metabolite levels measured by LC/MS/MS in 5-amino-1MQ-treated adipocytes (open bar) normalized to control untreated adipocyte (closed bar) levels in biological duplicates ( SD)

Unlike beta-2 agonists (clenbuterol, albuterol) which cause rapid receptor internalisation, beta-3 receptors in white adipose tissue demonstrate slower desensitisation kinetics

The peptide does not appear to bind a single dedicated receptor

At wave 1, a higher proportion of those classified with incident depressive symptoms were female, obese, had a higher burden of chronic and CVD and reported a higher use of antidepressant medications