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Genetic iron overload disorders

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The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

In a randomized, double-blind, placebo-controlled clinical study in 67 patients with severe traumatic brain injury, intravenous administration of dexanabinol (48 mg or 150 mg) within 6 hours of injury resulted in lower intracranial pressure and a reduced number of hypotensive episodes, indicating improvements in cerebral edema

Cell cytotoxicity assays A total of 1 10 5 cells/well in a 96-well plate were treated as indicated in figure legends or overexpressed with GSDME-NT