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2.2 Melatonin receptors and melatonergic ligands Melatonin regulates sleep and the circadian rhythm by activating two high-affinity G proteincoupled receptors, i.e., MT 1 and MT 2 ( 1 is expressed in the locus coeruleus (LC) and perifornical lateral hypothalamus (PFH), regulating the rapid eye movement (REM), while MT 2 is found in the thalamic reticular nucleus (TRN) in charge of the non-REM (NREM) activity (Waly and Hallworth, 2015)

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