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[15] Methionine donates methyl groups for the synthesis of S-adenosyl-methionine, which in turn drives phosphatidylcholine production and very-low-density lipoprotein assembly, facilitating export of triglycerides from hepatocytes and mitigating diet-induced steatosis

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In intervention studies, appropriate methodology includes the use of well-matched control groups, pre- and post-treatment testing, representative samples, sufficient sample sizes, random assignment, and procedures to eliminate bias