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J Biol Chem 280:2559025595 Hothorn M, Wachter A, Gromes R, Stuwe T, Rausch T, Scheffzek K (2006) Structural basis for the redox control of plant glutamate cysteine ligase

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Inflammatory stimuli such as LPS downregulate the expression of these proteins through the TLR4/NF-B and myosin light chain kinase (MLCK)/myosin light chain (MLC) signaling pathways, while sulforaphane (SA) can restore TJ protein expression and barrier function by inhibiting both pathways [70]

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