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Get out or die trying: peptide- and protein-based endosomal escape of RNA therapeutics

doi: 10.3389/fphar.2026.1789797 Received 16 January 2026 Revised 16 March 2026 Accepted 25 March 2026 Published 21 April 2026 Volume 17 - 2026 Edited by Thomas Hartung, Johns Hopkins University, United States Reviewed by Hartmut Jaeschke, University of Kansas Medical Center Research Institute, United States Kyunghee Yang, Simulations Plus, United States Updates Copyright 2026 Ghosh, Camara Dit Pinto, Malka-Markovitz, Cherkaoui, Sadeghi, Vierling and Gallo

doi: 10.1038/npp.2010.105 151 WilkinsonMBDiasCMagidaJMazei-RobisonMLoboMKKennedyPet al

L-carnitine helps oxygen entrance into the tri-carboxylic acid (TCA) cycle to synthesize ATP and consequently decreases the concentration of oxygen and reduces formation of ROS [35]

Current research increasingly highlights that soluble Tau species, particularly oligomers, are more synaptotoxic than insoluble neurofibrillary tangles (NFTs) (75)