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Sigmoidal dose-response curves and reliable estimates of IC50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 6)

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In Raw264.7 macrophages, PARP-1 activation promotes the nuclear translocation of LPS-induced NF-kB, and increased KC activation exacerbates alcohol-induced liver steatosis by increasing hepatic M1 macrophage marker gene expression

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The average age was 44.77 10.88 years, and the male to female ratio was 9:13