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Performing exploratory tests in vitro to predict toxicity in animals minimizes unnecessary in vivo testing and safeguards animal use

Collectively, these findings suggest that the antioxidant NAC treatment successfully rescued the exacerbated ROS generation, SGNs loss, and apoptosis caused by GPX1-deficiency after peroxynitrite damage

Studies suggest that IV antioxidant therapy can help manage neurofunctional pain by correcting deficiencies and reducing inflammation in the nervous system

One possible explanation, however, is that cysteine levels are elevated in the HepG2/C3A cells as part of a protective adaptation against the much higher oxygen tensions associated with cell culture systems

Sevgin K, Erguven P