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Lastly, the REDEFINE-4 clinical trial (NCT06131437) will evaluate the efficacy and safety of CagriSema compared to tirzepatide over 72 weeks in 800 adults with obesity [125]

Astrocytes indirectly promote OL survival by inducing apoptosis in CD4+ T cells 182 , and peripheral immune cells in MS produce leukaemia inhibitor factor (LIF) which protects OLs from TNF-induced death in vitro 183