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Metabolic Improvement: Helps regulate blood sugar and blood pressure

Loss of fumarate hydratase (FH) promotes fumarate accumulation, inhibition of mitochondrial replication factors and thus mtDNA mutation, culminating in glycolytic dependency and drug resistance [82]

[DOI] [PubMed] Hawking ZL

The design-expert program was used to display a contour and response surface graph to investigate the relationship between the independent factors and the response