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These are skincare ingredients with no performance-enhancing classification

[74] found that aldehyde dehydrogenase-2 deficiency (ALDH22) reduced the clearance of toxic aldehydes, resulting in additional ROS production, followed by aldehyde addition to mitochondrial proteins, leading to mitochondrial dysfunction, ATP depletion, and ROS accumulation

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Skin discoloration may look red on light skin and brown, purple or grey on darker skin

The use of capsaicin may be limited because many patients experience side effects such as burning [76]