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Day SM, Gironda SC, Clarke CW, Snipes JA, Nicol NI, Kamran H, et al

And antioxidant systems related to defend ferroptosis mainly including the xCT-GPX4, ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10), Guanosine triphosphate cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH4) and dihydroorotate dehydrogenase (DHODH)-dihydroubiquione (CoQH2) systems (5, 3 Similar features in SLE and ferroptosis 3.1 Iron accumulation Iron is one of the essential trace elements in the human body and is crucial for maintaining various biological functions, such as transporting oxygen, participating in the production of energy in the respiratory chain, and being involved in key biological reactions as a key component of various enzymes (34)

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Analytical determinations Glucose and ethanol were determined by an HPLC using the Rezex column at 80 C with an RI detector, at a flow of 0.8 mL min 1 of 5 mM H 2 SO 4