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Given the pharmacological limitations of existing PHGDH inhibitors, such as poor aqueous solubility and insufficient target specificity, nano-delivery systems have significantly improved tumor accumulation and therapeutic index through passive and active targeting strategies

The therapeutic potential of this dual mechanism was validated in a cisplatin-induced acute kidney injury model, where selenomethionine administration significantly attenuated renal damage through ferroptosis inhibition

Ive included some links to the supporting literature (see blue underlined text)

Early intervention candidates benefit most from minoxidil

J Bras Nefrol