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However, their efficacy data are limited, and their sedative effects can potentially induce hepatic encephalopathy in patients with chronic liver failure

Zhao LR, Xing RL, Wang PM, Zhang NS, Yin SJ, Li XC, Zhang L

Dermoscopic features of conjunctival, mucosal, and nail pigmentations in a case of Laugier-Hunziker syndrome

Because melanocortin modulation of energy homeostasis is centrally mediated, drug developers must overcome large pharmacokinetic hurdles for CNS penetration (6, 53, 141)