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However, the endothelial damage observed in ME/CFS patients does not appear to correlate with the usual markers of endothelial dysfunction seen in cardiovascular disease such as increased levels of symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA), and high-sensitivity C-reactive protein (hs-CRP), and reduced levels of arginine and homoarginine (311)

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This is particularly relevant for significant injuries, post-surgical recovery, chronic conditions that have resisted single-agent approaches, or patients dealing with both musculoskeletal and inflammatory components simultaneously

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