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PMID 19456324

Improve Mood : B12 plays a key role in neurotransmitter function, helping to keep mood swings in check and support mental clarity

doi: 10.3389/fendo.2020.00025 [DOI] [PMC free article] [PubMed] [Google Scholar] 287

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Notably, SIRT-3 has been shown to be downregulated by Angiotensin II receptor (AT2) in vitro , indicating that heightened levels of AT2, coupled with reduced deacetylase levels, may exert synergistic detrimental impacts on kidney function in the context of aging ( 2.2 Klotho levels decreased Klotho, a membrane-bound protein predominantly found in the kidney, was discovered over 20 years ago for its role as an antagonist of cellular aging