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addressing these gaps will significantly enhance the clinical relevance and depth of this field

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Acknowledgements We thank Professor Qianfei Wang (Beijing Institute of genomics, Chinese Academy of Sciences) and Professor Qianben Wang (Department of Pathology, Duke University School of Medicine, Durham, USA) for critical comments and advice on the manuscript

Deubiquitinated arrestins interact with G and enters the nucleus via importin complex, sequestering G from the receptor and G, which reduces receptor signaling efficiency (desensitization)