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It has also been shown to modulate pivotal inflammatory pathways, such as NF-B and MAPK 24,25 , although direct evidence within skin aging models remains limited

Introduction Cell death is a fundamental biological process that governs cell fate, tissue regeneration and host immune responses (1)

11 June 2025

For instance, elevated CHAC1 mRNA levels are associated with increased recurrence risk in these cancers, underscoring its clinical relevance ( Pan-cancer analyses reveal that CHAC1 expression is highly variable, being upregulated in many cancers (e.g., breast, ovarian, lung, bladder carcinomas) and downregulated in others (e.g., certain head/neck, kidney, and brain cancers) (Li, D